Wei-Cheng Lin, Chun-Yen Wang, Kuang-Jing Huang, Archan Chakraborty, Yu-Tsun Lin, Ya-Ju Hsieh, Kun-Yi Chien, Po-Yuan Ke, Wei-Han Huang, Chih-Yun Cheng, Ian Yi-Feng Chang, Hsiang-Yu Tang, Cheng-Hung Yang, Mei-Ling Cheng, Ying-Chih Chang, Chau-Ting Yeh, Chien-Kuo Lee, Jau-Song Yu, Yu-Sun Chang, Jörg Großhans, Li-Mei Pai*. (2026) HSPB8 regulates CTP synthase filaments to couple nucleotide metabolism and autophagy in tumors. bioRxiv 2026.02.10.704981.doi: 10.64898/2026.02.10.704981

Chia-Chun Chang, Min Peng, Gerson Dierley Keppeke, Li-Kuang Tsai, Ziheng Zhang, Li-Mei Pai, Li-Ying Sung, Ji-Long Liu. (2025) Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism. FEBS J. 2025 Jul;292(14):3676-3695. doi: 10.1111/febs.70086

Pei-Yu Wang, Archan Chakraborty, Hsin-Ju Ma, Jhen-Wei Wu, Anna C-C Jang, Wei-Cheng Lin, Hai-Wei Pi, Chau-Ting Yeh, Mei-Ling Cheng, Jau-Song Yu, Li-Mei Pai*. (2022) Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle. Development, 149(16). doi:10.1242/dev.200190

Chia-Liang Tsai, Ching-Yun Huang, Yi-Ching Lu, Li-Mei Pai, Daniel Horák, Yunn-Hwa Ma. (2022) Cyclic Strain Mitigates Nanoparticle Internalization by Vascular Smooth Muscle Cells. Int J Nanomedicine, 17, 969-981. doi:10.2147/IJN.S337942

Wen-Der Lin , Tan-Chi Fan , Jung-Tung Hung , Hui-Ling Yeo , Sheng-Hung Wang , Chu-Wei Kuo , Kay-Hooi Khoo , Li-Mei Pai , John Yu , Alice L Yu. (2021) Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer. Cancer Immunol. Res. 2021 Jan; 9(1):113-122. doi: 10.1158/2326-6066.CIR-20-0203.

Archan Chakraborty, Wei-Cheng Lin, Yu-Tsun Lin, Kuang-Jing Huang, Pei-Yu Wang, Yi-Feng Chang, Hsiang-Iu Wang, Kung-Ting Ma, Chun-Yen Wang, Xuan-Rong Huang, Yen-Hsien Lee, Bi-Chang Chen, Ya-Ju Hsieh, Kun-Yi Chien, Tzu-Yang Lin, Ji-Long Liu, Li-Ying Sung, Jau-Song Yu, Yu-Sun Chang and Li-Mei Pai*. (2020) SNAP29 mediates the assembly of histidine-induced CTPS filaments along cytokeratin network. Journal of Cell Science 139(9):ics240200. Doi:10.1242/jcs.240200.

Ming-Hsun Tsai, Li-Mei Pai, Chien-Kuo Lee. (2019) Fine-Tuning of type 1 interferon response by stat3. Frontier in Immuno. 10:1448. doi:10.3389/fimmu.2019.01448

Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju, Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh; Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, Li-Mei Pai*. (2018) Histidine-dependent protein methylation is required for the compartmentalization of CTP Synthase. Cell Reports, 24(10), 2733-2745 e2737. doi:10.1016/j.celrep.2018.08.007

Yu-Hung Lin; Yen-Yi Zhen; I-Ching Lee; Wei-Chi Lin; Mei-Yu Chen ; Li-Mei Pai*. (2017. 4) LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration. Molecular Biology of Cell. 28(8):1054-1065. SCI.

Li-Mei Pai*, Pei-Yu Wang, Wei-Cheng Lin, Archan Chakraborty, Chau-Ting Yeh, Yu-Hung Lin. (2016) Ubiquitination and filamentous structure of Cytidine triphosphate synthase. Fly (Austin), 10(3), 108-114. doi:10.1080/19336934.2016.1182268

Pei-Yu Wang, Wei-Cheng Lin, Yi-Cheng Tsai, Mei-Ling Cheng, Yu-Hung Lin, Shu-Heng Tseng, Archan Chakraborty, Li-Mei Pai*. (2015. 11) Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. Genetics. 201: 1511-1523. SCI. 

Shiun Chang, Li-Mei Pai, Chien-Kuo Lee. (2015.10) In vitro generation of murine plasmacytoid Dendritic cells from lymphoid progenitors using the AC-6 feeder system. JoVE. SCI.

Chia-Chun Chang, Wei-Cheng Lin, Li-Mei Pai, Hsuan-Shu Lee, Shinn-Chih Wu, Shih-Torng Ding, Ji-Long Liu*, Li-Ying Sung*.(2015.10) Cytoophidium assembly reflects upregulation of IMPDH activity. Journal of Cell Science. 128(19): 3550-3555. SCI.

W-H Lee, P-Y Wang, Y-H Lin, H-Y Chou, Y-H Lee, C-K Lee, L-M Pai *. (2014. 12) Effects of RING-SH2Grb2, a Chimeric Protein Containing the E3 Ligase Domain of Cbl, on the EGFR Pathway. Chinese Journal of Physiology. 57(6) SCI.

Gabriel N Aughey, Stuart J Grice, Qing-Ji Shen, Yichi Xu, Chia-Chun Chang, Ghows Azzam, Pei-Yu Wang, Luke Freeman-Mills, Li-Mei Pai, Li-Ying Sung, Jun Yan, Ji-Long Liu*. (2014.10) Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and daptive metabolism. Biology Open. 3(11): 1045-1056. SCI

Chou HY, Lin YH, Shiu GL, Tang HY, Cheng ML, Shiao MS, Pai LM*. (2014. 07) ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. J Biomed Sci. 19; 21(1): 64. SCI

Yi-Cheng Tsai, Wei Chiang, Willisa Liou, Wei-Hao Lee, Yu-Wei Chang, Yi-Chen Li, Pei-Yu Wang, Tsubasa Tanaka, Akira Nakamura, and Li-Mei Pai*. (2014, 2) Endophilin B is required for Drosophila oocyte to endocytose yolk downstream of Oskar. Development. 141 (3):563-573. SCI

Yi-Ling Chen, Ting-Ting Chen, Li-Mei Pai, Joanna Wesoly, Hans A.R. Bluyssen, and Chien-Kuo Lee. (2013, 10) A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. JEM. 210 (12), 2515-2522. SCI

Jen-Cheng Wang, Pei-Yu Wang, Hung-Ing Chen, Kai-Ling Wu, Li-Mei Pai, Tzer-En Nee*.(2013, 6) Lie Group Analysis of the Photo-Induced Fluorescence of Drosophila Oogenesis with the Asymmetrically Localized Gurken Protein. PLoSONE. 8:e65143. SCI

H Pi, YC Huang, IC Chen, CD Lin, HF Yeh, LM Pai. (2011, 06) Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila. J Biomed Sci. 17; 18: 42. SCI

Pei-Yu Wang and Li-Mei Pai*. (2011.02) D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoSONE. 6(2) e17097. SCI

Jen-Cheng Wang, Pei-Yu Wang, Ruo-Rung Huang, Wei-Chieh Lin, Chia-Hui Fang, and Li-Mei Pai, Tzer-En Nee*. (2011. 02) Lie group study of Raman spectra of the Gurken gradient in Drosophila oogenesis. Anal. Bioanal. Chem. 400:335-341. SCI

Nian-Kang Sun, Chun-Ling Sun, Chia-Hua Lin, Li-Mei Pai and Chuck C.-K. Chao*. (2010. 04) Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila. Journal of Biomedical Science, 17, 27. SCI

Chen-Hsin Liao, Shih-Chi Yeh, Ya-Hui Huang, Ruey-Nan Chen, Ming-Ming Tsai, Wei-Jan Chen, Hsiang-Cheng Chi, Pei-Ju Tai, Chia-Jung Liao, Sheng-Ming Wu, Wan-Li Cheng, Li-Mei Pai and Kwang-Huei Lin*.(2010.01) Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion. Endocrine-Related Cancer. 17(1):99-111 .SCI

Ju-Chien Cheng, Yung-Ju Yeh, Li-Mei Pai, Ming-Ling Chang and Chau-Ting Yeh*.(2009) 293 Cells Over-expressing Human ADI1 and CD81 are Permissive for Serum-derived Hepatitis C Virus Infection. Journal of Medical Virology, 81, 1560-1568. SCI

Lan-Sun Chen, Pei-Chi Wei, Taming Liu, Chung-Hsuan Kao, Li-Mei Pai and Chien-Kuo Lee*. (2009.02) STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. Journal of Biomedical Science, 16, 22. SCI

Wang, P.Y., Chang, W. L., and Pai, L.M*. (2008) Smiling Gurken gradient. Fly, 2:3, 1-3. SCI

Chang, W. L., Liou, W., Pen, H.C., Chou, H.Y., Chang, Y.W., Li, W.-H., Chiang, W. and Pai, L.M*. (2008) The gradient of Gurken, a long range morphogen, is directly regulated by Cbl-mediated endocytosis. Development, 135, 1923-1933. SCI

Pai, L.M*., Wang, P.Y., Chen, S.R., Barcelo, G., Chang, W.L., Nilson, L., and Schüpbach, T. (2006) Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mechanisms of Development, 123, 450-462. SCI

Pai, L.-M. Barcelo, G. and Schüpbach, T. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell. 103, 51-61.

Cox, R. T, Pai, L.-M., Kirkpatrick, C., Stein, J., and Peifer, M. (1999) Roles of the C Terminus of Armadillo in Wingless signaling in Drosophila. Genetics. 153, 319-332.

Cox, R. T, Pai, L.-M., Miller, J. R., Orsulic, S., Stein, J., McCormick, C. A., Audeh, Y., Wang, W., Moon, R. T., Peifer, M. (1999) Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. Development. 126, 1327-1335.

Pai, L.-M., Orsulic, S., Bejsovec, A., and Peifer, M. (1997) Negative regulation of Armadillo, a Wingless effector in Drosophila. Development. 124, 2255-2266.