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Metabolic enzymes form membraneless compartments to adapt to environmental changes. We demonstrate that histidine catabolism coupled with the folate cycle contributes to methionine synthesis, which promotes protein methylation. This post-translational modification in turn induces CTPS filament formation to preserve CTPS but reduces its enzymatic activity understarvation.

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The activity of CTP synthase is required for the collective border cell migration through the regulation of phospholipid distribution

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In vivo images of border cell migration

Control border cell cluster migration

CTPsyn mutant border cell cluster migration

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