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The CTP synthase (in green) re-locates on the cytokeratin network (in red) underglutamine deprivation stress


Metabolic enzymes form membraneless compartments to adapt to environmental changes. We demonstrate that histidine catabolism coupled with the folate cycle contributes to methionine synthesis, which promotes protein methylation. This post-translational modification in turn induces CTPS filament formation to preserve CTPS but reduces its enzymatic activity understarvation.

The activity of CTP synthase is required for the collective border cell migration through the regulation of phospholipid distribution


In vivo images of border cell migration
Control border cell cluster migration
CTPsyn mutant border cell cluster migration
